Xenobiotic Metabolism and Disposition

Download or read book Xenobiotic Metabolism and Disposition written by Harry P.A. Illing and published by CRC Press. This book was released on 1989-02-28 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such stud-ies.