A unique and practical high-level introductory guide to the emerging field of adaptive trial designs, platform trials, and master protocols.

With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of th

In the United States, a rare disease is defined by the Orphan Drug Act as a disorder or condition that affects fewer than 200,000 persons. For the approval of "

Platform trials test multiple therapies in one indication, one therapy for multiple indications, or both. These novel clinical trial designs can dramatically in

Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system r